Rotherham boss Paul Warne will be without three of his more experienced defenders in Richard Wood, Joe Mattock and Trevor Clarke for the Sky Bet League One clash with Accrington at the AESSEAL New York Stadium.
Sky Bet League Two leaders Forest Green should have player-coach Matt Mills and midfielder Kevin Dawson in contention again for the visit of Plymouth.
Coventry are confident of an injury boost ahead of their Sky Bet League One match against Rochdale at St Andrew’s on Saturday.
Gillingham will welcome back midfielder Ben Pringle for Saturday’s Sky Bet League One match against Lincoln at Priestfield.
Walsall must do without suspended defender Daniel Scarr as the Sky Bet League Two strugglers host Cambridge.
Cape Town City will be targeting more of the same when they travel to fellow stragglers Black Leopards in the Absa Premiership on Sunday afternoon.
Steve Komphela’s Golden Arrows will be aiming to stretch their unbeaten run in the Premiership to three games when defending champions Mamelodi Sundowns visit Durban on Sunday.
Southampton and Everton play out an early six-pointer on Saturday with both managers in serious danger of getting the boot.
Southampton head into the game sitting in 18th spot with just eight points from their opening 11 matches and with a torrid record on home soil.
Back-in-form AmaZulu will look to keep the winning run intact when they play host to Chippa United at Princess Magogo Stadium on Saturday.
Kaizer Chiefs will go into the second Soweto derby in seven days as clear favourites to get one over their great rivals, Orlando Pirates.